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Zepbound has not been studied in patients with a history of pancreatitis, or with severe gastrointestinal disease, including severe gastroparesis, and it is unknown if patients with a history of pancreatitis are at higher risk for developing pancreatitis on Zepbound

coli BL21(DE3)/RIL cells from pET21b(+) (Novagen) vectors and purified by denaturing gel filtration and ion exchange chromatography essentially as described 43

SCFAs are crucial for modulating intestinal epithelial barrier and bloodbrain barrier integrity, inflammatory responses, and endocrine signaling, playing a vital role in communication along the microbiota-gut-brain axis

Catharanthus roseus extract contains bioactive substances, including polyphenols acting as antioxidants