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In ccRCC patients, dysregulation of this pathway, characterized by hyperactivationis strongly linked to aggressive tumor behavior and unfavorable clinical outcomes

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Overall survival (OS) analysis of 241 eligible patients revealed that patients with high ALDH1A3 or ALDH3A1 expression had significantly worse survival than those with low ALDH1A3 or ALDH3A1 expression ( P = 0.005 and P = 0.032, log-rank test