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Additionally, astrocytes, which are normally involved in clearing excess glutamate and supporting neuronal function, become reactive in response to toxic environments

Included in the situations which may make dosage adjustments necessary are changes in clinical status secondary to remissions or exacerbations in the disease process, the patients individual drug responsiveness and the effect of patient exposure to stressful situations not directly related to the disease entity under treatment

As a general rule: The extent of hydrogen bonding increases as the total number of potential H-bond donors and acceptors increases between the species involved

Development and structure of skin