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[DOI] [PMC free article] [PubMed] [Google Scholar] Schalkwijk CG, Stehouwer CDA (2020) Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications, and other age-related diseases

The attack of ROS on the polypeptide backbone is initiated by an OH-dependent abstraction of the -hydrogen atom from an amino acid residue to form a carbon-centred radical

Published online January 1, 2001 2,099 View 21 Download Abstract PDF BACKGROUND Impaired insulin secretinn, peripheral insulin resistance, a disproportionately elevated rate of hepatic glucose production and influence of inherited or enviromental factors contribute to the pathogenesis of type 2 diabetes mellitus(DM)

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