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Oxidative stress releases pro-inflammatory molecules that interact with ROS to produce inflammation, performing major role in early onset of aging and metabolic diseases [7]

Similarly, in human lung carcinoma A549 cells, mangiferin exhibits antineoplastic properties, by inducing G2/M phase cell cycle arrest via downregulation of the cyclin-dependent kinase 1-cyclin B1 signaling pathway and inducing apoptotic cell death by inhibiting the PKC-NF-B pathway (55)

Our study aimed to the evaluation of the effect of testosterone on the livers functional and structural responses to hepatic I/R

Chemopreventive effects of curcumin on glandular stomach carcinogenesis induced by N-methyl-N'-nitro-N-nitrosoguanidine and sodium chloride in rats