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After FOXO4-DRI treatment, the staining of FOXO4 and p53-pS15 became weaker in the nucleus at 48 h and then disappeared with an accumulation in the cytoplasm at 72 h, especially in keloid fibroblasts

While topical cosmetic formulations containing copper peptides are widely available, injectable and advanced therapeutic applications are still evolving

Together, these mechanisms explain why GHK-Cu is considered one of the most promising compounds for non-hormonal hair restoration, supporting both new growth and the preservation of existing hair

Proper reconstitution, sterile handling practices, appropriate storage conditions, and consistent administration protocols are important for maintaining peptide stability and minimizing variability during research use