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65 For instance, both cancer and neurodegenerative diseases often involve increased oxidative damage, where impaired GST function may exacerbate disease progression

In contrast, our study confirmed decreased glutathione levels and increased ROS levels through BSO treatment or GCLC silencing, and revealed that while the depletion of glutathione did not compromise lymphoma cell survival in 2D culture, it sharply diminished viability in 3D gels