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Characterized by iron toxicity accumulation, phospholipid peroxidation and dysfunctional mitochondria, ferroptosis is intricately linked to the hepatic microenvironment, influencing and being influenced by factors such as iron homeostasis, glucose metabolism, lipid metabolism, amino acid metabolism, and the gut-liver axis

Le glutathion agit sur les rsidus chimiques en les rendant solubles dans l'eau, facilitant ainsi leur limination par les voies naturelles (bile, urine)

In parallel, tocopheryl glucoside, a stable, water-soluble derivative of vitamin E, contributes to sustained cellular antioxidant defense by promoting the regeneration of intracellular vitamin E 14

Furthermore, GCLC-KO mouse will serve as a useful tool to investigate the molecular mechanisms underlying neurodegeneration and in the development of new treatment strategies to address neurodegenerative diseases