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Patients develop early-onset neurological manifestations and neurodevelopmental disorders that are currently incurable (Falk, 2010)

10.1038/emboj.2012.165 23 Kretz-RemyC.MehlenP.MiraultM

Clinical translation of ferroptosis modulators also faces significant bottlenecks, including bioavailability, limited tissue specificity, and potential toxicity or off-target [134, 135]