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The Acap1 , whose expression was shown to be positively associated with the infiltrating level of immune cells in tumor microenvironment and the expression of immune checkpoint molecules 60 , exhibited stronger connections to its targets (e.g., Arhgap27os3, S1pr4 , and Garp ) in Xbp1 -/- compared to Ire1 -/-

The generation of lipoxidation products occurs due to oxidative stress within cells, which is instigated by an increase in ROS (Biswas and Mano 2021)

doi: 10.3389/fonc.2023.1193978 88 MiaomiaoSXiaoqianWYuweiSChaoCChenboYYinghaoLet al