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Topical agents are well-accepted options and seem particularly effective in acquired PE (Ciocanel et al., 2019

Therefore, the key direction for the future is to translate the above-mentioned mechanistic insights into biomarkers for patient stratification, so as to identify the specific immunometabolic states of patients (e.g., HIF-1-dominated hyperinflammatory type or Sirtuins-deficient immunosuppressive type)

Glycine betaine rather than acting only as an osmolyte also plays a role as regulator in cellular metabolism

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