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Keywords: Antioxidants, cerebral circulation, endothelial dysfunction, NRF2, oxidant stress, Protandim, reactive oxygen species, resistance arteries, salt, sodium, superoxide dismutase, vascular dysfunction, vasodilation INTRODUCTION Although oxidant stress has been implicated experimentally in a variety of human diseases including cardiovascular pathologies, clinical trials investigating oral antioxidant therapies in the prevention of morbidity and mortality have shown little-to-no benefit with antioxidant supplementation

TABLE 1 Mitochondria-targeted therapeutics

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