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The GD, through its direct interaction with 2, receives the hemicomplex from the CTD and enables its conformational maturation

Furthermore, the peptide ApoE-DBCO, capable of specifically binding to LDLR expressed on brain endothelial cells and glioma cells, was coupled to the azido group of nanoprobe through a Cu-free click cycloaddition reaction

Simultaneously, the TCA cycle is activated and this activation may be associated with the entry of BCAA metabolites into the TCA cycle, thereby providing tumor cells with energy and metabolic intermediates [150]