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A single 100 mg vial contains more elemental copper than the oral Tolerable Upper Intake Level for an entire day and roughly 30 to 50 times the daily copper dose that clinicians deliver intravenously to patients on total parenteral nutrition, where copper is dosed conservatively precisely because the parenteral route bypasses gut regulation

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Internationally, the World Medical Organization, American Medical Organization, the European Commission, the European Transport Safety Council, the World Health Organization, and many more have policies advocating for the lower from 0.08% to 0.05%