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Pharmacological GLP-1 RAs replicate these actions, aiding in managing Type 2 diabetes mellitus (T2DM) and promoting weight loss (23)

In a mouse cranial defect model, a 3Dprinted tricalcium phosphate/HA scaffold modified with these HAmiRNA nanocarriers produced significantly more new bone (higher bone volume fraction) and faster defect filling than an unmodified scaffold [114]

Dose: 2 mg (2000 mcg) daily after Week 1 titration

Following fixation with 4% paraformaldehyde for 30-60 min and nuclear staining with 0.02% DAPI (Sigma-Aldrich, #D9542) for 10 min, slices were scanned in a 20-fold magnification by using a Zeiss Axiovert 200M microscope equipped with Hamamatsu Orca Flash 4.0 camera and TissueFAXS scanning software (TissueGnostics, Vienna, Austria)