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For example, metformin, a well-studied HDT agent, not only limits excessive inflammation and tissue damage by modulating immune responses but also promotes autophagy through mTOR inhibition, thereby enhancing the clearance of M

In thyroid diseases, metabolic disorders associated with low-grade inflammation can also lead to an increased oxidative stress (68)

Unraveling novel roles of the mycobacterium tuberculosis transcription factor Rv0081 in regulation of the nucleoid-associated proteins Lsr2 and EspR, cholesterol utilization, and subversion of lysosomal trafficking in macrophages