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Additionally, metabotropic glutamate receptor 5 (mGluR5) physically associates with AQP4, modulating its permeability properties [417], while circadian regulators such as Per2 contribute to AQP4 polarization and glymphatic flow [418]

[DOI] [PubMed] [Google Scholar] 97.Divella R, De Luca R, Abbate I, Naglieri E, Daniele A

Disclosures: Kathryn Rhodes: Nothing to Disclose, Juliet Venter: Nothing to Disclose, Matthew McMillin: Nothing to Disclose, Sharon DeMorrow: Nothing to Disclose 2260 SIGNIFICANCE OF NEUTROPHIL-TO-LYMPHOCYTE RATIO IN BLEEDING AND PROGNOSIS AFTER ENDOSCOPIC TREATMENT OF CIRRHOTIC PATIENTS WITH ESOPHAGEAL VARICES Kazuto Takahashi 1 Takuto Nosaka 1 Yosuke Murata 1 RYOTARO SUGATA 1 Tomoko Tanaka 1 Yu Akazawa 1 Tatsushi Naito 1 Masahiro Ohtani 1 Yasunari Nakamoto 1 , 1 University of Fukui Background: Neutrophil-to-lymphocyte ratio (NLR) has been reported as a prognostic indicator in patients with cancer and some chronic inflammatory diseases by reflecting systemic inflammation and nutritional status