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Similar to ubiquitination, also SUMOylation occurs via a three-step cascade involving a single dimeric E1 enzyme, an E2 conjugating enzyme and E3 SUMO ligases attaching either SUMO1 or the highly related SUMO2/3 to the target

Regulatory T cells (Tregs), crucial regulators of inflammation, play a vital role in maintaining immune tolerance and homeostasis (219)

Highlights: Nearly half of women in Ireland, the UK, and Canada showed riboflavin deficiency Deficiency rates reached 72% in Malaysia, 82% in Cambodia, and 90% in Uganda More than half of UK adolescents aged 1117 years were riboflavin deficient Riboflavin deficiency vitamin B2 deficiency occurs when the body does not receive enough vitamin B2, a nutrient essential for energy production, iron metabolism, and normal cellular function

Glutathione plays a crucial role in supporting immune function and possesses potent antioxidant and detoxification properties