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Even with very low serum B12 concentrations (i.e., below 75pmol/L), clinically diagnosable symptoms of B12 deficiency are said to be apparent in only about 50% of people (Stabler et al., 1990)

It helps the peptide survive step one, but it does nothing to prevent first-pass metabolism in the liver

SLU-PP-332 Scientific Overview: Conclusion SLU-PP-332 scientific overview Likewise, evidence identifies the compound as a preclinical pan-ERR agonist with its greatest reported potency at ERR