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Nanodrugs such as NP@ESCu are engineered to efficiently induce cuproptosis at target sites (Guo et al., 2023)

Notably, these metabolic alterations also affect the neurodegenerative process: as a result, increased dietary lipid content offers neuroprotection and extends survival in mouse models of ALS (Dupuis et al., 2011), whereas restricting calorie intake exacerbates motor symptoms (Pedersen and Mattson, 1999