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Additional information Peptide Research Shortened Spadin Analogs Display Better TREK-1 Inhibition, In Vivo Stability and Antidepressant Activity (2017) Spadin, a sortilin-derived peptide, targeting rodent TREK-1 channels: a new concept in the antidepressant drug design (2010) In vitro and in vivo regulation of synaptogenesis by the novel antidepressant spadin (2015) (related to spadin mechanisms applicable to analogs) Spadin as a new antidepressant: absence of TREK-1-related side effects (2012) The Involvement of Sortilin/NTSR3 in Depression as the Progenitor of Spadin (2018) Role of TREK-1 in Health and Disease, Focus on the Central Nervous System (2019 review) Keep lyophilized peptides sealed in their original vial, protected from light and humidity, and store at -4F or colder for optimal long-term stability in research settings

It is being studied in diabetic neuropathy (NERVARA Phase 2 trial), sarcoidosis, and ischemic injury models

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Age differences in the prevalence and co-morbidity of DSM-IV major depressive episodes: results from the Who World Mental Health Survey Initiative