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A general limitation of this review should be highlighted: while the cited studies originate from all continents, to the best of our knowledge, no comparisons have been conducted across different ethnic groups

It is important to note that metformin can significantly affect the levels of various metabolites, including those involved in the glucose metabolism, lipid metabolism, tricarboxylic acid cycle (TCA), and urea cycle (t Hart et al., 2018a)

Infect Drug Resist 40474060

Furthermore, NPs derived from plants and coated with phytochemicals, and other vital bioactive compounds sourced from plant secondary metabolites may find application in treating foot or limb infections in individuals with diabetes (281, 282)