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However, since iron is a cellular transition element and its ionic forms participate in electron transfer reactions, it can also produce free radicals

Integrated analysis of microbiome and metabolome reveals disease-specific profiles in inflammatory bowel diseases and intestinal behet's disease

332,333,334 Specifically, IR leads to compensatory hyperinsulinemia, which stimulates GnRH gene transcription through MAPK pathway in PCOS and increases LH pulse secretion, thereby significantly increasing ovarian androgen synthesis

There may be other explanations why an effect could not be detected, such as a low sensitivity of the assessment method