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The water becomes the single unverified link in an otherwise verified chain

Breast cancer bone metastasis mediated by the Smad tumor suppressor pathway

Glossary GC gastric cancer HER2 human epidermal growth factor receptor 2 CPS combined positive score PD-L1 programmed cell death 1 ligand 1 FDA food drug administration TCM traditional Chinese medicine DHD4 DNA-binding protein 4 ABC ATP-binding cassette P-gp P-glycoprotein PI3K phosphatidylinositol-3-kinases Akt protein kinase B mTOR1/2 mammalian target of rapamycin complex 1/2 MRP1 multidrug resistance-associated protein 1 Bcl-2 B-cell lymphoma-2 MOMP mitochondrial outer membrane permeabilization BALF1 bamH1 A fragment leftward reading frame 1 TNF tumor necrosis factor NF B nuclear factor kappa-beta ANXA1 annexin A1 HULC highly up-regulated in liver cancer FoxM1 forkhead box protein M1 ATG5 autophagy-related protein 5 ROS reactive oxygen species MDA malondialdehyde GSH glutathione Keap1 kelch-like ECH-associated protein 1 Nrf2 NF-E2-related factor 2 DDR DNA damage response NER nucleotide excision repair PARP1 Poly (ADP-Ribose) polymerase 1 BER base excision repair ERCC excision repair cross-complementing gene TME tumor microenvironment CAFs cancer-associated fibroblasts SDF-1 stromal cell-derived factor-1 TAMs tumor-associated macrophages MSCs mesenchymal stem cells MDR1 multi-drug resistance 1 EMT epithelial-mesenchymal transition TGF transforming growth factor Rab31 Ras-related protein 31 MUC-1 mucin 1 WTAP wilms tumor 1 associated protein ADAR1 adenosine deaminases acting on RNA1 AZIN1 antizyme inhibitor1 CSC cancer stem cell AKAP-L8 PRKA kinase anchor protein 8L SCD1 stearoyl-CoA desaturase 1 MT1M metallothionein 1 M IGF2BP1 IGF2 mRNA binding protein 1 KHDRBS3 KH domain-containing RNA-binding signal transduction-associated protein 3 GLI1 glioma-associated oncogene homolog 1 SOX SRY-box transcription factor FUBP1 far upstream element-binding protein 1 MCM10 maintenance complex component 10 GRP75 glucose-regulated protein 75 NRP1 neuropilin 1 LDHA lactate dehydrogenase A ROR regulator of reprogramming HMGA2 high mobility group protein A2 TRIM14 tripartite motif 14 Dvl2 dishevelled 2 PIP3 phosphatidylinositol 3,4,5-trisphosphate FOXO forkhead box O PTEN phosphatase and tensin homolog deleted on chromosome 10 SIRT1 sirtuin1 KRAS kirsten rat sarcoma virus oncogene homologue DPD dihydropyrimidine dehydrogenase MAPK mitogen-activated protein kinases ERK extracellular signal-regulated kinase JNK c-Jun N-terminal kinase GRB growth-factor-receptor bound protein SOS son of sevenless FGFR fibroblast growth factor receptor ESRRG estrogen-related receptor gamma MDM murine double minute SLC7A11 solute carrier family 7 member 11 GPX glutathione peroxidase DRAM damage-regulated autophagy modulator STAT signal transducers and activators of transcription JAK janus kinase MGMT O6-methylguanine-DNA methyltransferase CIP2A cancerous inhibitor of PP2A TCF T-cell factor LEF lymphoid enhancer-binding factor References 1 BrayFLaversanneMSungHFerlayJSiegelRLSoerjomataramIet al