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One of the most well-established pathways involves the overexpression of ATP-binding cassette (ABC) transporters, particularly P-glycoprotein (P-gp), encoded by the MDR1 gene

Consistent with these observations, animal models with iHSP72 overexpression exhibit improved insulin sensitivity and reduced systemic inflammation, reinforcing its therapeutic relevance

Hormonal Influences Hormones such as insulin and glucagon modulate carnitine biosynthesis by altering the activity of key enzymes

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