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Front Cell Dev Biol 11:1332049 Zhang DD (2025) Thirty years of NRF2: advances and therapeutic challenges

Partial Agonism and Signaling Bias Orforglipron functions as a partial agonist at the GLP-1 receptor, meaning it produces submaximal activation compared to full agonists such as native GLP-1 or semaglutide

Adenoviral-mediated methods to overexpress sarcoplasmic-endoplasmic reticulum Ca2+/ATPase (SERCA) have shown promise in preclinical and early-phase clinical trials

Further complicating the impact of this disease, mild and moderate hypertension are usually asymptomatic, and their presence (and the subsequent increase in cardiovascular risk) is often unrecognized