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The first D2B strategy applied to the development of PROTACs was reported in 2020, in which Robert et al

PPD contains mycobacterial antigens that upregulate interleukin-2 (IL-2), IL-4, IL-5, and interferon- (IFN-), inducing a Th1-mediated immune response

BPC-157 is typically studied for its interaction with nitric oxide signaling and vascular regulatory pathways, while TB-500 is associated with actin cytoskeleton regulation and cellular migration signaling