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Investigation includes liver function tests, renal function, full blood count, and imaging if malignancy or liver disease suspected

In addition, inhibition of the proteasome causes the accumulation of unfolded and misfolded proteins, which triggers unfolded protein response (UPR), endoplasmic reticulum (ER) stress, and apoptosis (Obeng et al., 2006)

Thyroid replacement therapy in CKD patients with low thyroid hormone (even those not showing clinical signs of hypothyroidism) may improve glomerular filtration (Shin, Lee 2012