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doi: 10.1073/pnas.1117773108 101 MullenARWheatonWWJinESChenPHSullivanLBChengTet al

reported that inhibition of the Xc- transport system using sulfasalazine, while ineffective as a monotherapy, was highly effective to eliminate AML cell lines when combined with Buthionine sulfoximine (BSO), an inhibitor of glutamyl cysteine synthetase, the first enzyme in the synthesis of GSH