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FA can also induce the direct activation of the NLRP3 inflammasome in macrophages

As an example, the last update of WHO classification (5th edition) incorporated (i) CDKN2A/B homozygous deletion in IDH -mutant astrocytomas (covering grades 24), (ii) TERT promoter mutation, EGFR amplification, and + 7/ 10 copy number changes in IDH -wildtype diffuse astrocytomas as well as (iii) MYB- or MYBL1 mutations in diffuse astrocytoma

Discussion In this study, we set out to replicate the findings of our prior studies examining the relationship between depression and antidepressant treatment with TL and TA in a new cohort of unmedicated medically healthy individuals with MDD