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Symptoms are the same as for chronic liver disease: Weight loss Jaundice Swelling in the stomach and ankles Confusion and fatigue Passing blood in your poop or vomiting blood A few liver cells die every time the liver filters alcohol

Hepatocytes, the predominant parenchymal cells, are primarily responsible for the livers metabolic, detoxifying and synthetic activities, including alcohol metabolism.6 However, non-parenchymal cells, such as HSCs, Kupffer cells (KCs), infiltrating macrophages, neutrophils and liver sinusoidal endothelial cells (LSECs), are equally vital in maintaining liver homeostasis and orchestrating its response to alcohol-induced damage.7 The intricate crosstalk between these parenchymal and non-parenchymal cells is key to understanding the progression of ALD (figure 1)

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10.1084/jem.20130315 J