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Description

Understanding these metabolic changes may uncover new therapeutic opportunities and strategies to overcome resistance mechanisms

These drawbacks already indicate the necessary future developments: Of great importance is clearly the further development of the three mentioned methods, but also the finding of novel techniques which will allow the analysis of the actual cell metabolism of host cell and pathogen under in vivo infection conditions

Interestingly, Tex functionality can be restored with metabolic manipulation, as described above, through PGC-1 overexpression (121, 147), further supporting the notion that ability to maintain OXPHOS and FAO metabolism are necessary to avoid Tex phenotype

Real-time PCR analysis revealed that in HA or HA + GSH cell cultures, mRNA levels of inflammatory markers (cytokines and catabolic enzymes) were significantly down-regulated