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For example, the role of macrophages in inflammation has moved away from the dichotomy of pro-inflammatory M1 and anti-inflammatory M2 cells, being replaced by a more nuanced view, encompassing a diversity of heterogeneous macrophage sub-types, likely with specialized functions [36]

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169,170 IL-2 can fine-tune immune responses and maintain self-tolerance, 171 and its deficiency accounts for the occurrence of autoimmune diseases

After 4 min, the operator switched the participant to the re-breathing circuit, and a precisely measured bolus of 0.8 mlkg 1 body mass of 99.997% chemically pure CO (CO N47, Air Liquide, Paris, France) was injected into the circuit