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Mechanistically, lactate accumulation, driven by PKM2, enhances Twist1-K150la, which in turn facilitates Twist1 phosphorylation, nuclear translocation, and regulation of TGFB1 transcription, thereby inducing an EndoMT-associated fibrotic phenotype in ischemic flaps

The SDGs (20152030) comprise 17 interconnected objectives intended to guide the international community towards a more equitable and sustainable future, with 169 specific targets for different dimensions of social health, economic, and institutional improvement

The cells were treated with blank LPs, free ASX, ASX-LPs, and Lf-ASX-LPs (equivalent to 18 M of ASX) for 6 h, washed with PBS, and incubated in medium containing 0.5 mg/mL MTT for 4 h