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Diagnosis of cats in cohort 2 was based on renal pathology findings, including assessments on global glomerulosclerosis, fibrosis, inflammation, and tubular atrophy, by a board-certified nephropathologist at a veterinary renal pathology laboratory (Columbus, OH), available health history, as well as clinical observations

Gaussian accelerated Molecular Dynamics (GaMD) simulations also show that this loop is flexible when NSD2 is absent but is restricted when NSD2 is bound (Supplementary Movie 1 and Supplementary Figs