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Multi-omics work in Reynoutria japonica and other knotweeds similarly points to dispersed but co-regulated gene sets rather than a single compact biosynthetic gene cluster, suggesting that AQ pathways in plants often emerge from distributed networks rather than classical microbial-style clusters ( Flavonoids, in contrast, are synthesized exclusively via the phenylpropanoid pathway, which branches from aromatic amino acid metabolism when phenylalanine ammonia-lyase (PAL) converts L-phenylalanine to trans -cinnamic acid

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To avoid the effects of small subgroups, effects sizes were calculated in two ways

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