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doi: 10.29245/2572.942X/2019/1.1262 150 BettenDPRichardsonWHTongTCClarkRF

PMID: 10791689

Here, we report on such a dual engineering approach, where the REW substitutions in IgG1 resulted in favorable pharmacokinetics in human FcRn expressing mice, combined with increased ability to activate the classical complement pathway in an on-target manner