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Its prevalence increases significantly with age, rendering it the principal cause of blindness globally, responsible for approximately 48% of blindness cases [35]

We previously succeeded in identifying human ACF in situ using magnifying colonoscopy with methylene blue staining, and showed that the number of rectal ACF increased in a stepwise fashion from normal subjects to adenoma patients, and then to cancer patients, suggesting that ACF are precursor lesions to the adenomacarcinoma sequence in humans 13, 14

Dyspnea is a normal manifestation of heavy physical or psychological exertion, but also may be caused by underlying conditions (both pulmonary and extrapulmonary)