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Nat Rev Drug Discovery (2018) 17(9):688

Together, these data support the conclusion that the primary impact of the S10D mutation is on IRGQ engagement and the basal organization of ATG8-positive structures, rather than on global autophagy induction or lysosomal delivery of LC3 under stress

They contribute significantly to various aspects of brain function, including brain development, learning and memory processes, and the maintenance of CNS homeostasis

Best Pract Res Clin Endocrinol Metab 16 : 433437 Dupont J and LeRoith D (2001) Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction