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In vitro studies demonstrated cytotoxic activity in HepG2 cells and human liver cells L-02, leading to cell death, and demonstrated in in vivo studies that flavokavain B is responsible for the potentiation of kava hepatotoxicity upon herbdrug interaction in C57BL/6 mice

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In weight loss, HCG is sometimes used alongside a low-calorie diet to mobilize stored fat (though this remains controversial)

Newly synthesized cytosolic GSH is then actively transported into the mitochondria via the recently identified GSH importer SLC25A39