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Moreover, elevated AR activity may impair antioxidant defences through NADPH depletion, thereby limiting glutathione (GSH) regeneration and exacerbating oxidative stress 10,52 ( Figure 7 )

Injecting randomly throughout the day produces isolated pulses that may not align with downstream anabolic pathways, reducing the metabolic impact per injection

This study received ethical committee approval from the Ethics Committee of the Second Hospital of Shandong University with written informed consent obtained from each participant prior to enrollment