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In the 50s, when chemotherapy wasnt yet available, massive doses of B12 shots were given to children with a neuroblastoma tumor every two days, for 2-3 years with great success: NEUROBLASTOMA: AN EVALUATION OF ITS NATURAL HISTORY AND EFFECTS OF THERAPY, WITH PARTICULAR REFERENCE TO TREATMENT BY MASSIVE DOSES OF VITAMIN B12

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A safety review in the Journal of Obesity & Food Metabolism describes six randomized, double-blind, placebo-controlled trials evaluating AOD-9604, including oral dosing studies and longer phase II programs