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Given the connection between the SGOC and the methionine cycle through folate, a decrease in serine concentration leads to a decrease in GSH

A second hydrogen peroxide molecule acts as a reducing agent to regenerate the resting state enzyme, producing a molecule of oxygen and water.36 Hydrogen peroxide though at low amounts tends to regulate some physiological processes such as signaling in cell proliferation, cell death, carbohydrate metabolism, mitochondrial function, and platelet activation and maintenance of normal thiol redox-balance,37 however, at high concentrations it has been reported to be very deleterious to cells.38 Hence, the ability of CAT to effectively limit H2O2 concentration in cells underlines its importance in the aforementioned physiological processes as well as being a first line antioxidant defense enzyme

The gut-liver axis plays a crucial role in NAFLD pathophysiology, with dysbiosis contributing to disease progression

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