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For example, means to alter the PE molecule in a manner that does not substantially affect the functional advantages provided by the PE molecules described here can also be used and such resulting molecules are intended to be covered herein

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Clinical evidence from hand OA studies reveals significant alterations in gut microbiome-derived tryptophan metabolites: serum levels of 5-hydroxyindoleacetic acid (5-HIAA) and 5-hydroxytryptophan (5-HTP) are elevated, whereas 3-HAA is reduced in symptomatic patients (Wei et al., 2023)

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