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When the gap shrinks, overdose is less likely

doi: 10.1128/iai.68.2.429-436.2000

(PubMed) Curhan GC, Willett WC, Speizer FE, Stampfer MJ

The decreased levels of portal insulin, provided there is still portal flow at all in end-stage cirrhosis, make the remaining hepatocytes even more GH-resistant [8]