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eBioMedicine (2022) 76:103861

Phytother Res 32(6):10731079

Furthermore, OHP causes damage to both neuronal and nonneuronal mitochondria, leading to oxidative stress burden mediated by the redox-sensitive TRPA1 channels, which correlate with OHP-induced cold and mechanical hypersensitivity [71, 115,116,117]

Indeed, proteasome-dependent proteolysis of carbonylated proteins that were extensively present in late log phase epimastigote cultures was suggested to signal metacyclogenesis (Cardoso et al., Nucleotides Synthesis and DNA Replication Cellular DNA synthesis and proliferation, as well as DNA repair mechanisms depend on the production of a balanced supply of deoxyribonucleotides (dNTPs)