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Captured mouse IgG was detected using an AP-conjugate anti-mouse IgG (Fc-specific from goat (Sigma-Aldrich, A9316) (diluted 1:5000 in PBS/T/S) and visualized by addition of AP-substrate (10 ug/mL in diethanolamine buffer) (Sigma-Aldrich)

8), increased PPP1R18 expression ( P = 3.75 10 7 ) and multiple other genes in the region (Supplementary Fig

3.1.2 Oxidative stress Sies (1991) first defined OS as the accumulation of ROS and cellular damage caused by the imbalance between pro-oxidant and antioxidant systems. ROS are a group of chemically reactive molecules and ions with high oxidizing activity, including superoxide anions, peroxides, and free radicals, which play important roles in cell signaling and tissue homeostasis (Ferreira et al., 2018)

Goh XX, Tang PY, Tee SF (2022) Effects of antipsychotics on antioxidant defence system in patients with schizophrenia: a meta-analysis