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The linear mixed-effects model (LMM) was constructed to account for both fixed and random effects, ensuring a robust analysis of the longitudinal data, so we applied LMM to analyze the longitudinal outcome variables including instrument scores (for patients 37 and 920) and LPP substrate amplitudes (for patients 1120), for which the model included fixed effects for relapse status and time (different time points [TPs], defined in Supplementary Methods 3.8 and 9.3) and a random effect of patient ID

ABCR, Karlsruhe, Germany) were used as starting materials

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