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The observed increase in mitochondrial malate and cytosolic 2-oxoglutarate through elevated SLC25A11 expression aligns with the systemic energetic dysregulation and oxidative stress reported in plasma metabolomic studies in ME/CFS patients

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87 Unlike other amino acid sensors that inhibit GATOR2 in the absence of their respective ligands, SAMTOR interacts with and activates GATOR1 in the absence of methionine or SAM 70,71 (Fig