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Global, regional, and national burden of stroke and its risk factors, 1990-2019: a systematic analysis for the global burden of disease study 2019

Seligson DB, Horvath S, McBrian MA, Mah V, Yu H, Tze S et al

This connection was also confirmed by Zhu et al.s (2018) group who found that upregulation of RIPK3 triggers ER stress which subsequently increased Ca 2+ overload and xanthine oxidase activity leading to overproduction of ROS, all of which was reduced by RIPK3 deletion

There are many outside factors that increase free radical damage number one is the sun and many others include air pollution, smoking, foods, chemicals in everyday products, and the air we breathe